Which symptom is frequently associated with a deep vein thrombosis in the lower extremity?

Calf tenderness is a classic symptom associated with deep vein thrombosis (DVT) in the lower extremity. When a clot forms in a deep vein, often in the legs, it can lead to swelling and inflammation in the affected area which manifests as tenderness and pain, especially when the muscle is palpated or when the foot is flexed upward (known as Homan's sign). This symptom is a crucial indicator for healthcare providers as it can help in the diagnosis of DVT.

In contrast, extreme weakness is not a specific symptom of DVT and may relate to a number of other conditions or systemic issues. Severe throbbing pain in the chest is more indicative of a pulmonary embolism, which can occur if a DVT progresses to cause a blockage in the lungs. Persistent diarrhea does not have a direct correlation with DVT and could suggest gastrointestinal issues rather than vascular problems. Thus, calf tenderness stands out as the relevant symptom linked to a deep vein thrombosis.